Intrinsic factor

Definition

Intrinsic factor is a protein produced by cells in the stomach lining. It is needed for the intestines to absorb vitamin B12 efficiently.

Information

In a disease called pernicious anemia, immune system damage to the stomach lining can cause a lack (deficiency) of intrinsic factor. Pernicious anemia causes vitamin B12 deficiency, which leads to a low red blood cell count (anemia).

Intrinsic factor deficiencies can also be caused by other reasons, such as:

  • Inherited conditions
  • Other diseases
  • Surgical removal of the stomach

References

Antony AC. Megaloblastic anemia. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 170.

Antony AC. Megaloblastic anemia. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 39.

See also:

  • Disease

    Pernicious anemia

    Megaloblastic anemia - view of red blood cells

    Pernicious anemia is a decrease in red blood cells that occurs when the body cannot properly absorb from the gastrointestinal tract. Vitamin B12 is necessary for the proper development of red blood cells. Pernicious anemia is a type of . See also:

  • Nutrition

    Vitamin B12

    Vitamin B12 benefits

    Vitamin B12 is a water-soluble vitamin. Water-soluble vitamins dissolve in water. After the body uses these vitamins, leftover amounts leave the body through the urine. The body can store vitamin B12 for years in the liver.

Review date:
January 31, 2010
Reviewed by:
Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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