The Genebank at Scripps Clinic Registry

Inclusion Criteria:

Candidates for this study must meet ALL of the following criteria:

• Age 18 years or older
• Be reliable, cooperative and willing to comply with all protocol-specified procedures and sub-study if consented.
• Able to understand and grant informed consent
• Have at least one of the following (a-g):
• 1. Coronary Artery Disease (defined as):
• Coronary artery bypass surgery or
• Lesion >70% on cardiac or CT angiogram or
• Percutaneous Coronary Intervention
• 2. Myocardial infarction (defined as):
• Diagnosed by elevated troponin level or
• Diagnosed by ST segment elevations on EKG or
• Diagnosed by pathologic Q waves on EKG or
• Documented in the medical record or by self report
• 3. Atrial Fibrillation (defined as):
• Lone Atrial fibrillation (paroxysmal, persistent or permanent); OR
• Lone Atrial Flutter (paroxysmal, persistent or permanent)
• 4. Automatic Internal Cardiac Defibrillator
• 5. Aortic Stenosis (defined by):
• Calculated Aortic Valve Area ≤ 1.0 cm² or
• Mean Pressure Gradient ≥ 40 mmHg or
• Peak Pressure Gradient ≥ 64 mmHg or
• Dimensionless Index < .25 or
• Prior or planned Aortic Valve Replacement for Aortic Stenosis
• 6. Mitral Regurgitation (insufficiency) (defined as)
• Moderate to Severe (equivalent to +3 to +4) mitral regurgitation (insufficiency) on transthoracic echocardiogram as determined by the reading physician and structurally abnormal valve (i.e. myxomatous) and/or thickened or redundant leaflets; OR
• Prior or planned Mitral Valve repair or replacement for mitral regurgitation
• 7. Idiopathic (non-ischemic) Cardiomyopathy (defined as):
• Diagnosed < age 40; OR
• Non-ischemic etiology confirmed by cardiac angiography or CT angiography (may have non-obstructive or stable coronary artery disease if diagnosis of non-ischemic etiology of CM is established by cardiologist).

Exclusion Criteria:

Patients will be excluded if ANY of the following conditions apply:

• Previously enrolled in The Genebank at Scripps Clinic Registry
• Any active bleeding (i.e. GI bleed).
• Has a significant medical condition which in the investigator's opinion may interfere with the patient's optimal participation in the study
• Treatment with any investigational agents or devices within 30 days preceding enrollment in the study.
• Been administered or taken any CNS sedatives or depressants in the past 12 hours.
• Been administered or taken any CNS sedatives or depressants in the past 12 hours.
• Subject's qualifying diagnosis is Atrial fibrillation and they are known to have any one of the following:
• 1. Prior myocardial infarction, coronary artery bypass surgery, or percutaneous coronary intervention
• 2. EF < 45% at time of diagnosis (excluding tachycardia induced cardiomyopathy diagnosed by a cardiologist)
• 3. Elevated left atrial pressures (> 20 mmHg)
• 4. Dilated left atrium (> 4.0 cm or >2.0 cm/m2 body surface)
• 5. Mitral valve disease with significant valve pathology
• Mitral regurgitation/insufficiency greater than trace to mild on echo as determined by reading physician
• Rheumatic mitral valve disease
• 6. Congestive heart failure prior to diagnosis
• 7. Hypertrophic cardiomyopathy
• 8. Diagnosis following coronary artery bypass or valve replacement surgery
• 9. Post heart transplant
• 10. Congenital heart disease
• 11. Diagnosed in setting of hyperthyroid
• 12. COPD
• 13. Obstructive sleep apnea
• Subject's qualifying diagnosis is Aortic Stenosis and they are known to have any one of the following:
• 1. Bicuspid valve or other congenital abnormality of the aorta or aortic valve
• 2. Evidence of Rheumatic involvement of the Aortic Valve
• Subject's qualifying diagnosis is Mitral regurgitation (insufficiency) and they are known to have any one of the following:
• 1. Ejection fraction <50%
• 2. Evidence of significant ischemic disease with regions of akinetic myocardium
• 3. Rheumatic changes on echocardiogram (as determined by the reading physi4ian)
• 5. Significant Mitral stenosis (greater than "mild" on echocardiogram as determined by the reading physician) 6. Evidence of valve perforation 7. Evidence of congenital abnormality (i.e. cleft valve)
• Subject's qualifying diagnosis is Idiopathic (non-ischemic) cardiomyopathy and they are known to have any one of the following:
• 1. Ischemic cardiomyopathy
• 2. Hypertrophic cardiomyopathy
• 3. Viral cardiomyopathy
• 4. Alcohol/drug induced cardiomyopathy