Also known as: Polyneuropathy - chronic inflammatory, CIDP, Chronic inflammatory polyneuropathy or Guillain-Barré - CIDP
- Problems walking due to weakness or lack of feeling in the feet
- Trouble using the arms and hands or legs and feet due to weakness
- Sensation changes, such as numbness or decreased sensation, pain, burning, tingling, or other abnormal sensations (usually affects the feet first, then the arms and hands)
- Electromyography (EMG) to check the muscles and the nerves that control the muscles
- Nerve conduction tests to check how fast electrical signals move through a nerve
- Nerve biopsy to remove a small piece of a nerve for examination
- Spinal tap (lumbar puncture) to check the fluid that surrounds the brain and spinal cord
- Blood tests may be done to look for specific proteins that are causing the immune attack on the nerves
- Corticosteroids to help reduce inflammation and relieve symptoms
- Other medicines that suppress the immune system (for some severe cases)
- Plasmapheresis or plasma exchange to remove antibodies from the blood
- Intravenous immune globulin (IVIg), which involves adding large numbers of antibodies to the blood plasma to reduce the effect of the antibodies that are causing the problem
- Permanent decrease or loss of sensation in areas of the body
- Permanent weakness or paralysis in areas of the body
- Repeated or unnoticed injury to an area of the body
- Side effects of medicines used to treat the disorder
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a disorder that involves nerve swelling and irritation (inflammation) that leads to a loss of strength or sensation.
CIDP is one cause of damage to nerves outside the brain or spinal cord (peripheral neuropathy). Polyneuropathy means several nerves are involved. CIDP often affects both sides of the body.
Health care providers also consider CIDP as the chronic form of Guillain-Barré syndrome.
The specific triggers of CIDP vary. In many cases, the cause cannot be identified.
CIDP may occur with other conditions, such as:
Symptoms include any of the following:
Other symptoms that can occur with CIDP include:
Exams and Tests
The health care provider will perform a physical exam and ask about the symptoms, focusing on the nervous system and muscles.
Tests that may be ordered include:
Depending on the suspected cause of CIDP, other tests, such as x-rays, imaging scans, and blood tests, may be done.
The goal of treatment is to reverse the attack on the nerves. In some cases, nerves can heal and their function can be restored. In other cases, nerves are badly damaged and cannot heal, so treatment is aimed at preventing the disease from getting worse.
Which treatment is given depends on how severe the symptoms are, among other things. The most aggressive treatment is only given if you have difficulty walking or if symptoms don't allow you to care for yourself or work.
Treatments may include:
The outcome varies. The disorder may continue long term, or you may have repeated episodes of symptoms. Complete recovery is possible, but permanent loss of nerve function is not uncommon.
Complications of CIDP include:
When to Contact a Medical Professional
Call your provider if you have a loss of movement or sensation in any area of the body, especially if your symptoms get worse.
Katirji B. Disorders of peripheral nerves. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016:chap 107.
Shy ME. Peripheral neuropathies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 420.
- Review date:
- December 07, 2016
- Reviewed by:
- Amit M. Shelat, DO, FACP, Attending Neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School of Medicine, Stony Brook, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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