Also known as: Hutchinson-Gilford progeria syndrome and HGPS
- Growth failure during the first year of life
- Narrow, shrunken or wrinkled face
- Loss of eyebrows and eyelashes
- Short stature
- Large head for size of face (macrocephaly)
- Open soft spot (fontanelle)
- Small jaw (micrognathia)
- Dry, scaly, thin skin
- Limited range of motion
- Teeth - delayed or absent formation
- Insulin resistance
- Skin changes similar to that seen in scleroderma (the connective tissue becomes tough and hardened)
- Generally normal cholesterol and triglyceride levels
- Heart attack (myocardial infarction)
Progeria is a rare genetic condition that produces rapid aging in children.
Progeria is a rare condition. It is remarkable because its symptoms strongly resemble normal human aging, but it occurs in young children. In most cases, it is not passed down through families. It is rarely seen in more than 1 child in a family.
Exams and Tests
The health care provider will perform a physical exam and order laboratory tests. This may show:
Cardiac stress testing may reveal signs of early atherosclerosis of blood vessels.
Genetic testing can detect changes in the gene (LMNA) that causes progeria.
There is no specific treatment for progeria. Aspirin and statin medicines may be used to protect against a heart attack or stroke.
Progeria Research Foundation, Inc. -- www.progeriaresearch.org
Progeria causes early death. People with the condition most often only live to their teenage years (average lifespan of 13 years). However, some can live into their early 20s. The cause of death is very often related to the heart or a stroke.
Complications may include:
When to Contact a Medical Professional
Call your provider if your child does not appear to be growing or developing normally.
Gordon LB, Brown WT, Collins FS. Hutchinson-Gilford progeria syndrome. Gene Reviews. Seattle, WA: University of Washington: 2015:1. PMID: 20301300 www.ncbi.nlm.nih.gov/pubmed/20301300. Accessed August 1, 2015.
- Review date:
- January 08, 2015
- Reviewed by:
- Chad Haldeman-Englert, MD, FACMG, Fullerton Genetics Center, Asheville, NC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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