Bone marrow (stem cell) donation

Also known as: Stem cell transplant and Allogeneic-donation


Bone marrow is the soft, fatty tissue inside your bones. Bone marrow contains stem cells, which are immature cells that become blood cells.

People with life-threatening diseases, such as leukemia, lymphoma, and myeloma can be treated with a bone marrow transplant. This is now often called a stem cell transplant. For this type of treatment, bone marrow is collected from a donor. Sometimes a person may donate their own bone marrow.

Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood.

Types of Bone Marrow Donation

There are two types of bone marrow donation:

  • Autologous bone marrow transplant is when people donate their own bone marrow. "Auto" means self.
  • Allogenic bone marrow transplant is when another person donates bone marrow. "Allo" means other.

With an allogenic transplant, the donor's genes must at least partly match the person's genes. A brother or sister is most likely to be a good match. Sometimes parents, children, and other relatives are good matches. But only about 30% of people who need a bone marrow transplant can find a matching donor in their own family.

Bone Marrow Registries

The 70% of people who do NOT have a relative who is a good match may be able to find one through a bone marrow registry. The largest one is called Be the Match ( It registers people who would be willing to donate bone marrow and stores their information in a database. Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant.

How to Join a Bone Marrow Registry

To be listed in a bone marrow donation registry, a person must be:

  • Between the ages of 18 and 60
  • Healthy and not pregnant

People can register online or at a local donor registry drive. Those between the ages of 45 to 60 must join online. The local, in-person drives only accept donors who are younger than age 45. Their stem cells are more likely to help patients than stem cells from older people.

People who register must either:

  • Use a cotton swab to take a sample of cells from the inside of their cheek
  • Give a small blood sample (about 1 tablespoon)

This tissue is then tested for special proteins, called human leukocytes antigens (HLA). HLAs help your infection-fighting system (immune system) tell the difference between body tissue and substances that are not from your own body.

Bone Marrow Matching

Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. If a donor's HLAs match well with a person who needs a transplant, the donor must give a new blood sample to confirm the match. Then, a counselor meets with the donor to discuss the bone marrow donation process.

What Happens During a Bone Barrow Donation

Donor stem cells can be collected in two ways.

Peripheral blood stem cell collection. Most donor stem cells are collected through a process called leukapheresis.

  • First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood.
  • During the collection, blood is removed from the donor through a line in a vein (IV). The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient.
  • The red blood cells are returned to the donor through an IV in the other arm.

This procedure takes about three hours. Side effects include:

  • Headaches
  • Sore bones
  • Discomfort from needles in the arms

Bone marrow harvest. This minor surgery is done under general anesthesia. This means the donor will be asleep and pain-free during the procedure. The bone marrow is removed from the back of your pelvic bones. The process takes about an hour.

After a bone marrow harvest, the donor stays in the hospital until he or she is fully awake and can eat and drink. Side effects include:

  • Nausea
  • Headache
  • Fatigue
  • Bruising or discomfort in the lower back

You can resume normal activity in about a week.

There are very few risks for the donor and no lasting health effects. Your body will replace the donated bone marrow in about 4 to 6 weeks.


American Cancer Society. Stem Cell Transplant (Peripheral Blood, Bone Marrow, and Cord Blood Transplants). Available at: Accessed August 28, 2015.

American Society of Clinical Oncology. Donating Bone Marrow. American Society of Clinical Oncology. Available at: Accessed August 28, 2015.

Be the Match: How marrow donation works; Steps of PBSC or bone marrow donation. Available at: Accessed August 28, 2015.

National Cancer Institute. Blood-forming Stem Cell Transplants. Available at: Accessed August 28, 2015.

Review date:
July 10, 2014
Reviewed by:
Christine Zhang, MD, medical oncologist, Fresno, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
Copyright Information A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2008 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.