This research is comparing the effectiveness of an oral drug (Cambia) to an injectable drug (ketorolac) for the treatment of severe migraine headaches. Requires one office visit that will last about 2 hours and one follow-up telephone call.
Be between the ages of 18 and 65 years old.
Have a current migraine diagnosis.
Have a current headache lasting greater than or equal to 36 hours.
Be currently pregnant or nursing.
Have used Cambia in the past.
Have a history of gastritis, gastric ulcer, or GI bleed.
Have a diagnosis of kidney or liver insufficiency.
Have a previous reaction or intolerance to non-steroidal anti-inflammatory medications
Severe migraines often require treatment in a hospital or emergency room (ER) since the drugs approved to treat migraines need to be injected. Cambia is a non-steroidal anti-inflammatory drug that can be taken orally at home which could make it easier and less expensive for patients and insurance companies, since it does not require a trip to the doctor or the ER. This study is comparing the two drugs to see if Cambia is as effective as ketorolac for the acute treatment of severe migraines.