Investigational drug treatment for advanced liver cancer.

Trial ID:
IRB-19-7342
Catherine Frenette, MD
The purpose of this study is to test the effectiveness, safety and tolerability of two investigational drugs in combination with one another for the treatment of advanced liver cancer.

Pembrolizumab (Keytruda) is an immunotherapy that works with your immune system to help fight certain cancers. Lenvatinib (Lenvima) belongs to a type of anti-cancer treatment known as receptor tyrosine kinase inhibitors (RTKIs). Tyrosine kinases are proteins involved in the growth of cells and the development of new blood vessels that supply them and can be present in high amounts in cancer cells. By blocking their action on cell receptors lenvatinib may slow the rate at which the cancer cells grow and help to cut off the blood supply that feeds the cancer.

Patients in this study will be assigned by chance to receive pembrolizumab with lenvatinib OR lenvatinib alone.

Requires 1-2 clinic visits every 3 Weeks.

Inclusion Criteria

  • Be adult men or women, 18 years of age or older with advanced liver cancer.
  • Have adequately controlled blood pressure, with or without medication.

Exclusion Criteria

  • Have received prior treatment for advanced liver cancer.
  • Have a bleeding or clotting disorder.
  • Have any condition that might affect the absorption of oral medication.
  • Have a serious non-healing wound, ulcer, or bone fracture

Additional Info

  • All treatments and physician visits during this study will take place at Scripps Clinic Torrey Pines

Contact Info: