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Combined Oral and IV Chemotherapy for Advanced or Metastatic Solid Tumors

Trial ID:
IRB-20-7498
Sonia Ali, MD
This is a Phase 2 study to assess the safety and preliminary effectiveness of an investigational anti-cancer medication, rebastinib, combined with a current approved medication, paclitaxel, in patients with advanced or metastatic solid tumors. This is an open-label study which means you will know which drugs you are receiving. All treatments and physician visits during this study will take place at Scripps Clinic Torrey Pines.

Inclusion Criteria

  • Be 18 years of age or older
  • Have a confirmed diagnosis of a locally advanced or metastatic solid tumor
  • Be eligible to receive paclitaxel chemotherapy
  • Have cancer that has progressed, despite standard therapies
  • Agree to contraception requirements through 120 days following last dose
  • Meet all other eligibility criteria

Exclusion Criteria

  • Have received prior systemic anti-cancer treatment within 28 days
  • Be pregnant or lactating, or expecting to conceive or father children within the defined study duration
  • Have other significant medical conditions that would interfere with the study, in the physician’s opinion

Additional Info

  • Rebastinib is an inhibitor of a molecule that acts in cancer growth and cancer cell survival, called “TIE2”. Paclitaxel is approved by the FDA as single therapy and in combination with other chemotherapy medications in a variety of cancer types. The dosage of rebastinib being administered is based on safety data from the prior cohorts of patients in part 1b of this study.
  • Rebastinib will be taken orally twice daily. Paclitaxel will be given intravenously in the clinic on Days 1, 8, and 15 of each 28 day cycle.
  • Patients will receive study treatment until they develop progressive disease, experience unacceptable toxicity, or withdraw from the study.

Contact Info:

  • Clinical Research Services
  • CRSLeadership@scriphealth.org