Precise Treatment for Pediatric Cancers
Nowhere is proton therapy’s precise ability to target tumors more valuable than when treating pediatric cancers. Because they are still growing, children and teens are particularly sensitive to damage from radiation treatments. Though the original cancer may be treated successfully, radiation exposure in other organs can lead to future problems.
The most advanced facility of its kind in Southern California, Scripps Proton Therapy Center uses precisely focused radiation to help overcome these challenges. Protons deposit their highest doses directly in tumors, reducing exposure to healthy tissue. As a result, children with cancer can receive therapeutic doses with fewer side effects and a reduced chance of radiation-induced secondary cancers.
The radiation oncologists at Scripps Proton Therapy Center work with the pediatric cancer team at Rady Children’s Hospital to ensure comprehensive treatment and support for families coping with childhood cancers.
Proton Therapy for Pediatric Cancer Treatment
Focusing radiation specifically on tumors brings tremendous benefits for pediatric patients. This is particularly true with brain and spinal cancers. When treating brain tumors, the ability to reduce the amount of radiation exposure to normal tissue, away from the tumor, means fewer developing neurons are exposed. In the spine, precise targeting translates into less radiation in surrounding tissues, such as heart, lung, stomach and reproductive organs.
Because pediatric patients are so sensitive to radiation therapy, proton beam is an effective option for many cancers. Ependymoma, a common malignant brain tumor in children, is a prime example, as radiation treatments can cause cognitive decline in children and adolescents. Other side effects can include impaired hearing, hormonal issues and secondary cancers.
Because proton therapy is so accurate, treatment can be enhanced for some patients. Aggressive cancers can be treated with higher doses. Recurrent cancers can be targeted despite previous radiation treatments.
This accuracy is even further enhanced by Scripps’ advanced imaging and pencil beam scanning technology, which focuses a narrow proton beam — smaller than the width of a pencil — to precisely target tumors.
Types of childhood cancers treated
The pediatric cancer specialists at Scripps Health and Rady Children’s Hospital use proton therapy to treat a variety of pediatric cancers, as well as non-malignant tumors, including:
Pediatric head, neck and brain tumors:
- Astrocytoma and other gliomas, including optic pathway/hypothalamic glioma, oligodendroglioma, oligoastrocytoma, anaplastic astrocytoma
- Atypical teratoid/Rhabdoid tumors
- Intracranial germ cell tumors (germinoma)
- Nasopharyngeal carcinoma
- Juvenile angiofibromas
- Ewing’s sarcoma / Primitive neuro-ectodermal tumor (PNET)
- Desmoid tumor
- Histiocytosis X
What to expect
Each child’s therapy is precisely tailored to their needs. Patients, parents and clinicians collaborate closely to create a personalized treatment plan. The number and length of treatments will vary, based on the cancer. How patients respond depends on many factors, including the types of treatments they are receiving. Many kids tolerate proton therapy well and continue to perform normal activities. However, individual responses vary.
Proton therapy is a highly precise form of external radiation therapy that can be used for tumor control in select pediatric patients. All cancer treatments have advantages and disadvantages. Be sure to discuss these, as well as treatment options, with your pediatric cancer specialist.
Evidence Supporting Proton Therapy for Pediatric Cancers
- A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameningeal rhabdomyosarcomas
- Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation
- Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: clinical outcomes and dosimetry compared to intensity modulated radiation therapy
- Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function
- Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques?