Study of Idiopathic Disease in Humans

Inclusion Criteria

• Have a disease or condition that, despite ongoing care and follow-up by a physician or other health care provider, remains undiagnosed.
• The disease or condition may benefit from the use of genomic strategies for suggesting new diagnoses and/or novel interventions (i.e., the symptoms appear genetic based on either family history or a sign that the symptoms have a shared underlying cause)
• Has disease or condition that is serious and/or severe (i.e., life and/or quality-of-life threatening as determined by the Clinician Panel)
• Has a life expectancy of more than 6 months
• Has a physician who is willing to participate in the study, who will accept responsibility for return of genomic results and any clinical decision-making on the basis of any results provided

Exclusion Criteria

• Has a significant medical or psychiatric condition, which, in the medical judgment of the Clinician Panel, may interfere with participation
• Is unwilling or unable to grant informed consent if they do not have a legal guardian who has authority to sign a consent form on their behalf.