Scripps Clinic, TSRI Scientists Receive Funding for Parkinson's Research

$2.4 million awarded by CIRM to study possible stem cell-based therapy

A provider in holding a patient's hadn.

$2.4 million awarded by CIRM to study possible stem cell-based therapy

Scientists at Scripps Clinic and The Scripps Research Institute (TSRI) have received a grant of nearly $2.4 million from the California Institute for Regenerative Medicine (CIRM) to support safety and quality tests of a potential stem cell therapy for Parkinson’s disease.

The new three-year project will be led by Jeanne Loring, professor of developmental neurobiology at TSRI. Loring will be partnering with Melissa Houser, MD, neurologist and medical director of the Parkinson’s Disease and Movement Disorders Center at Scripps Clinic.

“What sets our study apart from many others is that it’s patient-specific,” Dr. Houser said. “Our hope is that this grant will help to begin a new era of long-term treatment for Parkinson’s disease.”

“The goal is to restore the quality of life for Parkinson’s patients,” Loring said. “The methods we’re using will raise the bar for quality considerably—for all kinds of cell therapy.”

Focus on dopamine production

Parkinson’s disease strikes when specialized neurons in the brain begin dying. These neurons produce dopamine, a chemical messenger that maintains normal nerve-firing patterns. Without dopamine, patients suffer from tremors, a lack of balance and even speech difficulties.

For the study, the Loring lab will investigate induced pluripotent stem cells (iPSCs), which are derived from adult subjects and can differentiate into any kind of cell in the body. In this case, iPSCs derived from cells donated by 10 Scripps Clinic Parkinson’s patients were developed into dopamine-producing neurons—the same kind that die during Parkinson’s.

Could lead to human tests

The new grant will allow the researchers to advance these cells through U.S. Food and Drug Administration preclinical testing requirements, with the hope of moving closer to clinical trials.

Loring’s work focuses in part on improving the quality and safety of stem cell therapies. She and her colleagues recently published the first comprehensive analysis of genomic sequence of iPSCs, and her lab’s advances include the development of the PluriTest quality control assay for pluripotency (the ability of stem cells to differentiate), which was recently licensed to The Coriell Institute for Medical Research.

The grant number is DISC2-09073.

Learn more about Scripps Health, a nonprofit integrated health system in San Diego, Calif.

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Keith Darce

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