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Invasive nerve ablation procedure for relief of heart failure symptoms.

Trial ID:
IRB-21-7827
Rajeev Mohan, MD
The Axiom System is an investigational device designed to deliver radiofrequency ablation to the greater splanchnic nerve (GSN) to normalize key heart and lung pressures and reduce symptoms of heart failure. Study requires five visits over 24 months.

Inclusion Criteria

Patients must:
  • Be 40 years of age or older
  • Have chronic heart failure diagnosis
  • Be currently taking treatment with oral diuretic for 30 days or more
  • Have an LVEF = 50 % determined by echocardiogram within the past 6 months.

Exclusion Criteria

Patients must not:
  • Have a BMI > 45 kg/m2
  • Have a history of clinically significant liver cirrhosis
  • Be dialysis dependent
  • Have chronic pulmonary disease requiring continuous home oxygen.
  • Be unable to walk less than 100 meters OR a distance greater than 450 meters in six minutes.

Additional Info

  • Eligible participants will be randomized to either ablation using the Axon System (treatment cohort) or a sham procedure (control cohort). Participants will have post-procedure follow-up visits at 7 days, and 1, 3, 6 and 12-months.

Contact Info:

  • CRS Leadership
  • CRSLeadership@scrippshealth.org